CircO2 Ingredients: 420 mg Blend, Forms and Dose Limits

CircO2 ingredients include several quantified nutrients and a four-component proprietary blend. This page examines what the panel can tell you, how to interpret blend bounds and which formulation questions remain useful. For the overall buying decision, see the CircO2 review.

Entry	Form	Amount/tablet	Transparency	Buyer implication
Vitamin C	Magnesium ascorbate and ascorbic acid	100 mg	Disclosed	Can compare nutrient overlap.
B12	Methylcobalamin	1,000 mcg	Disclosed	Percentage is not a benefit measure.
Magnesium	Magnesium ascorbate	4 mg	Disclosed	Small labeled contribution.
Four-part blend	Beet root, hawthorn, citrulline, sodium nitrite	420 mg total	Individual amounts unspecified	Cannot reconstruct exposure.
Other ingredients	Sugar alcohols, binders, flavors and other aids	Individual amounts unspecified	Names listed	Ask about tolerance and specific allergens.

What the blend arithmetic can and cannot show

The 420 mg total constrains the ingredients without revealing their distribution. Four components share that amount, so 105 mg is their arithmetic average, not an actual ingredient dose. At two tablets the entire blend totals 840 mg. No component can exceed that daily total, and the other ingredients occupy some of it.

Calculation	Result	Meaning
420 mg / 4 components	105 mg average	A mathematical mean, not a reconstructed formulation.
420 mg × 2 tablets	840 mg whole blend/day	An upper bound for one ingredient, not its dose.
840 / 6,000 × 100	14% maximum	Comparison with the citrulline amount in Figueroa (2016), not percent efficacy. Figueroa et al. (2016) [1]

This bound can exclude equivalence to the cited 6 g citrulline regimen at one or two tablets. It cannot rule out every effect from the other ingredients or establish that more tablets would be useful or safe.

Active ingredients: form and exposure matter

A botanical name alone does not establish a studied chemical exposure. CircO2 lists beet root powder and hawthorn extract without separate amounts. Nitrite and nitrate are different substances. Comparing powder weight with beet juice volume skips the standardization needed for a meaningful exposure comparison, even when both interventions concern nitric oxide biology.

Active	Disclosed amount	Research relevance	Interpretation
Beet root powder	Part of 420 mg blend	Kapil studied nitrate-rich juice, not an unspecified powder fraction. Kapil et al. (2015) [2]	Nitrate content cannot be calculated from this panel.
Hawthorn berry extract	Part of blend	NCCIH describes mixed or insufficient evidence for many heart-related uses. NCCIH [4]	Extract type and standardization matter.
L-citrulline	Part of blend	Figueroa studied 6 g/day for 14 days in young overweight men. Figueroa et al. (2016) [1]	The blend ceiling is much lower; population and outcomes also differ.
Sodium nitrite	Part of blend	Its inclusion is relevant to the nitrate/nitrite/NO pathway.	No component amount established; do not equate with dietary nitrate juice.
Vitamins C/B12 and magnesium	100 mg / 1,000 mcg / 4 mg	Nutrient functions differ from proof of improved circulation from the finished formula.	Disclosed amounts help assess overlap with other supplements.

CircO2 Supplement Facts panel listing vitamins, magnesium, the proprietary blend and the other tablet ingredients — The published panel supplies ingredient order and totals but not separate amounts for the four-component blend.

Chart comparing the entire CircO2 blend ceiling with the citrulline dose in one human study — This visual compares labeled total blend bounds with one citrulline trial; it does not compare clinical efficacy.

Sweeteners, tablet binders and allergen questions

The excipient list is relevant if sugar alcohols or flavors bother you. The list includes mannitol, xylitol, cellulose ingredients, magnesium stearate, natural flavor and color, silica and stevia extract. Quantities are unspecified. For a specific allergy, request ingredient-source and cross-contact information rather than assuming the listed names establish that the tablet is suitable.

Mannitol and xylitol are sugar alcohols; individual gastrointestinal tolerance varies.
The panel names natural flavor and color without a complete source breakdown.
Plant-based magnesium stearate does not certify the entire product as vegan or allergen-free.
Check the delivered label for formulation changes and ask about the exact allergen you need to avoid.

The active magnesium amount is 4 mg, which is different from the amount of magnesium stearate used as a manufacturing aid. These entries should not be added together as if both were declared nutritional magnesium.

Questions to take to a clinician or pharmacist

Bring the actual panel and explain why you want to use CircO2. A review is more useful when it connects a specific symptom or goal with your medicines and existing supplements. It should also identify which ingredient amounts would change the decision.

A hidden dose is a reason to request information, not permission to invent a safe exposure.

Does my intended use need diagnosis or a better-supported intervention first?
Does sodium nitrite or hawthorn change the assessment with my prescriptions?
Am I already taking B12, vitamin C or another nitric oxide product?
Would a fully quantified single ingredient be easier to assess for my particular goal?

For ingredient education beyond this brand, use the Ingredient Research library. The effectiveness page explains why a formula mechanism is different from evidence of an outcome.

Frequently asked questions

Does CircO2 disclose nitrate content?

The inspected panel lists beet root powder without a standardized nitrate quantity. It separately lists sodium nitrite inside the shared blend. That does not provide a combined nitrate dose or allow conversion into the nitrate exposure used in a beet juice trial.

Is hawthorn berry the same as every researched hawthorn extract?

No. Species, plant part, extraction method and standardization can differ. CircO2 names a berry extract inside the blend, so conclusions from a separately specified leaf-and-flower preparation cannot automatically be transferred. Ask for the exact extract specification if that distinction affects your decision.

Can the blend average reveal the formula?

Dividing 420 mg by four gives 105 mg, but the ingredients need not be equally distributed. The average is a mathematical descriptor only. It cannot tell you how much citrulline, nitrite, beet root or hawthorn is actually present in a tablet.

Does the B12 percentage prove stronger energy benefits?

The panel’s high B12 Daily Value percentage describes nutrient quantity relative to a reference intake. It is not a measure of energy gained or the probability of benefit. The clinical question includes deficiency status and the cause of fatigue, not just the label percentage.

Should I increase tablets to match a citrulline study?

No research-dose comparison here recommends increasing CircO2. Every additional tablet also increases sodium nitrite, hawthorn and the other ingredients. Because their individual doses are undisclosed, multiplying tablets cannot safely reproduce a single-ingredient trial and may create an inappropriate combination.

Check the seller’s latest ingredient panelResolve component quantities before comparing with research. Affiliate link; we may earn a commission.

Complete CircO2 assessment series

Biraj Health Care — Biraj K., M.Ed.

Biraj Health Care is Biraj K.’s editorial identity. His M.Ed. in Health Education is from Tribhuvan University; it is not a medical licence. Method: a document-based assessment of the published panel, dated seller terms and cited human research. Ingredient studies and finished-formula evidence are distinguished; no hands-on testing or medical review is claimed.

Methodology · Sources Policy · Dietary Supplements Guide · Ingredient Research

Educational information, not personal medical advice. Do not change prescribed treatment on the basis of this assessment.

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References

Product facts and transaction terms were checked against the seller’s dated product panel and offer on November 3, 2026. These establish advertised terms, not independent clinical outcomes.